XAFTY®

A broad-spectrum antiviral for XAFTY®

About XAFTY® Necessity of XAFTY® Vision of XAFTY®

XAFTY® is a broad-spectrum antiviral that activates intracellular autophagy, enabling the body to eliminate viruses after they have entered host cells. Through this mechanism, it demonstrates strong therapeutic efficacy across a wide range of viral diseases, including COVID-19.

Its active ingredient, niclosamide, has shown efficacy against 31 viral infections—including COVID-19, SARS, MERS, Ebola, HIV, and influenza—highlighting its potential as a versatile treatment option for various viral diseases.

Antiviral Efficacy of Niclosamide, the Active Ingredient in XAFTY®

In the scientific community, extensive efforts have been made to rapidly identify antiviral agents by screening FDA-approved drugs for antiviral activity. As a result, in the early 2000s, niclosamide was found to exhibit antiviral properties against the SARS virus.

Subsequent studies have shown that niclosamide is effective not only against SARS but also against a wide range of viruses, including Zika virus, hepatitis viruses, and Ebola virus. Notably, its antiviral activity has been demonstrated regardless of viral family, highlighting its potential as a broad-spectrum antiviral agent.

※ Niclosamide : The active ingredient in Yomesan, an antiparasitic drug first introduced in Germany in 1962 by Bayer. Its safety has been well established over decades of use and it is listed on the WHO Model List of Essential Medicines.

Family	Virus Name	Associated Diseases	Approved Treatment	Reference
Coronaviridae	MERS-CoV	MERS	✕	Gasen et al., Nature Communications (2019) 10:5770
	SARS-CoV-1	SARS	✕	Wu et al., Antimicrobial Agents and Chemotherapy (2004) 48, 2693–2696
	SARS-CoV-2	COVID-19	Remdesivir, Paxlovid, Lagevrio	Jeon et al., Antimicrobial Agents and Chemotherapy (2020) 64(7): e00819-20
Retrovirus	Human Immunodeficiency Virus (HIV)	AIDS	Zidovudine, Zalcitabine, Stavudine, Abacavir, Didanosine, etc.	Jeon et al., Antimicrobial Agents and Chemotherapy (2020) 64(7): e00819-20
Adenoviridae	Human Adenovirus	Acute Infection, Respiratory Disease	✕	Jeon et al., Antimicrobial Agents and Chemotherapy (2020) 64(7): e00819-20
Flaviviridae	Zika virus	Microcephaly in Infants	✕	Simeonov et al., Nature Medicine (2016) 22, 1101–1107
	Dengue virus 2 (DENV-2)	Dengue Fever	✕	Li et al., Cell Research (2017) 26, 1046–1064
	West Nile virus (WNV)	West Nile Fever	✕	Li et al., Cell Research (2017) 26, 1046–1064
	Yellow fever virus (YFV)	Yellow Fever	✕	Li et al., Cell Research (2017) 26, 1046–1064
	Japanese encephalitis virus (JEV)	Japanese Encephalitis	✕	Li et al., Cell Research (2017) 26, 1046–1064
	Hepatitis C virus (HCV)	Hepatitis C	Mavyret, Harvoni, Sovaldi, etc	Edwards et al., Journal of Medicinal Chemistry (2011) 54, 8670–8680
Hepeviridae	Hepatitis E virus (HEV)	Hepatitis E	✕	Edwards et al., Journal of Medicinal Chemistry (2011) 54, 8670–8680
Filoviridae	Ebola virus	Ebola	✕	Madrid et al., ACS Infectious Diseases (2015) 1, 317–326
Orthomyxoviridae	Influenza virus	Flu	Rapivab, Relenza, Tamiflu, etc.	Jurgel et al., PLoS Pathogens (2012) 8(10): e1002976
Picornaviridae	Human Rhinovirus (HRV)	Common Cold	✕	Jurgel et al., PLoS Pathogens (2012) 8(10): e1002976
Picornaviridae	Coxsackievirus (CV)	Hand, Foot, and Mouth Disease (HFMD)	✕	Jurgel et al., PLoS Pathogens (2012) 8(10): e1002976
Herpesviridae	Herpes virus 1 (HSV-1)	Herpes	✕	Jurgel et al., PLoS Pathogens (2012) 8(10): e1002976
	Epstein–Barr virus (EBV)	Infectious Mononucleosis	✕	Huang et al., Antiviral Research (2017) 38, 68–78
	Kaposi’s sarcoma–associated herpesvirus (KSHV)	Kaposi’s Sarcoma	✕	Huang et al., Antiviral Research (2017) 38, 68–78
Togaviridae	Chikungunya virus (CHIKV)	Chikungunya Fever	✕	Wang et al., Antiviral Research (2016) 135, 81–90
	Sindbis virus (SINV)	Sindbis Fever	✕	Wang et al., Antiviral Research (2016) 135, 81–90
	Semliki Forest virus (SFV)	Semliki Forest Fever	✕	Wang et al., Antiviral Research (2016) 135, 81–90
Arenaviridae	Lassa virus (LASV)	Lassa Fever	✕	Herring et al., Antimicrobial Agents and Chemotherapy (2021) 65(4)
Pneumovirida	Respiratory Syncytial Virus (RSV)	Acute Respiratory Infection	✕	Nyomdecha et al., Virus Research (2021) 295:198277